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题目：Heteromeric Assembly and Modulation Mechanisms of AMPA Receptors
演讲人：Yan Zhao，Ph.D, 
Postdoctoral Fellow
Vollum Institute at Oregon Health and Science University
时间：2019年5月23日星期四13:00-14:00
地点：吕志和楼B106
摘要：
Glutamate-gated AMPA receptors mediate the fast component of excitatory signal transduction at chemical synapses throughout all regions of the mammalian brain. AMPA receptors are tetrameric assemblies composed of four subunits, GluA1-4. Despite decades of study, the subunit composition, subunit arrangement and molecular structure of native AMPA receptors remain unknown. Here we elucidate the structures of 10 distinct native AMPA receptor complexes by single particle cryo-EM. We find that receptor subunits are arranged non stochastically, with the GluA2 subunit preferentially occupying the B and D positions of the tetramer and with triheteromeric assemblies comprising a major population of native AMPA receptors. Cryo-EM maps define the structure for S2-M4 linkers between the ligand binding and transmembrane domains, suggesting how neurotransmitter binding is coupled to ion channel gating.
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