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题目：Neuronal architecture of cytoneme-mediated paracrine signaling
讲座人：Hai Huang，Ph.D.
Postdoctoral Scholar, 
Cardiovascular Research Institute, 
University of California San Francisco
时间：2019年4月3日（星期三）13:00-14:00
地点：金光生命科学大楼411
摘要：
While virtually all cells in an animal’s body communicate with their neighbors, many scientists thought that only neurons — the specialized cells that comprise much of the brain and nervous system — produced the structures that allowed them to transmit and receive signals directly over long distances. Most scientists believed then that non-neural cells communicated by releasing molecules that waft around the extracellular fluid until they were taken up by neighboring cells. But our group discovered wire-like projections, cytonemes, and show that these structures function like cellular railways, precisely delivering molecular messages to faraway cells. Non-neural cells send out cytonemes and form synapses that resemble those that neurons make. Cytonemes facilitate cell-cell communication using neurotransmitters, the same molecular signals that neurons use to convey sensory information. Molecular complexes responsible for sending and receiving the signal on either side of the cytoneme synapse are the same as those found on the equivalent sides of neural synapses. Thus, cytoneme signaling has many of the remarkable attributes of neuronal signaling, such as quantitative, temporal and spatial specificity.
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