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题目：CasX enzymes comprise a distinct family of RNA-guided genome editors
讲座人：Junjie Liu, Ph.D.
Postdoctoral fellow, University of California, Berkeley
时间:2019年3月28日（星期四）13:00-14:00
地点：金光生命科学大楼411
摘要：
Archaea and bacteria utilize CRISPR-Cas for adaptive immunity against invading nucleic acid. RNA-guided DNA binding and cutting have proven to be transformative tools for genome and epigenome editing across wide-ranging cell types and organisms. Despite extensive effort, just two kinds of CRISPR-Cas nucleases, Cas9 and Cas12a (Cpf1), provide the foundation for this revolutionary technology. Metagenomic analysis of microbial DNA from groundwater samples revealed a new protein, CasX which is a hybrid enzyme containing elements of both Cas9 and Cas12a as well as novel RNA folds and protein domains, establishing this enzyme family as the third CRISPR-Cas system effective for genetic manipulation. The compact size of CasX (<1000 amino acids), DNA cleavage characteristics and derivation from non-pathogenic microorganisms offer important advantages relative to existing genome editing technologies.
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