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Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1

Single-cell RNA-seq analysis of mouse preimplantation embryos by third-generation sequencing

A-to-I RNA editing in honeybees shows signals of adaptation and convergent evolution

PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations

Auxin response factors (ARFs) differentially regulate rice antiviral immune response against rice dwarf virus

Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells

Structural insight into the assembly and conformational activation of human origin recognition complex

Touch-induced seedling morphological changes are determined by ethylene-regulated pectin degradation

Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia

China’s rare birds may move north as the climate changes, new data suggest

Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells

Compartmentalized β1-adrenergic signalling synchronizes excitation–contraction coupling without modulating individual Ca2+ sparks in healthy and hypertrophied cardiomyocytes

Single-cell patterning and axis characterization in the murine and human definitive endoderm

SAUR17 and SAUR50 Differentially Regulate PP2C-D1 during Apical Hook Development and Cotyledon Opening in Arabidopsis

Combinatorial regulation of gene expression by uORFs and microRNAs in Drosophila

Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation

Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer

Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1